Post Doctoral Fellow - Biochemistry and Molecular Biology - #390531

Medical University of South Carolina

Date: 08/19/2021 23:00 PM

City: Charleston, South Carolina

Contract type: Full Time

Work schedule: Full Day

Job no: 534044

Entity: MUSC University

Department: COLLEGE OF MEDICINE - COM-Biochemistry & Molecular

Sub Department: UNIV-2211000-Biochemistry & Molecular Biology

Work type: Full-Time

Employee Type: UNIV - Post Doc

Location: Charleston, SC-Downtown

Categories: Allied Health & Laboratory Services, Research

Pay scale: UNIV-Band 0: Commensurate with experience.

FLSA: Salaried

Job Summary:
The department of Biochemistry & Molecular Biology at MUSC has an opening for a motivated and collegial Post-Doctoral fellow in the laboratory of Dr. Tim Barnoud, which will join MUSC on November 1st. The Barnoud lab focuses on the p53 tumor suppressor, the most frequently mutated gene in human cancer. Specifically, the lab is seeking to understand the impact of genetic variants in p53 on cancer risk and response to therapy. A second goal of the Barnoud lab is to identify novel therapeutic strategies in gastrointestinal (GI) cancers, including pancreatic cancer. The candidate should be highly motivated with a recent Ph.D. degree, or a Graduate Student about to receive a Ph.D. degree, and a solid background and skills in molecular/cell biology and biochemistry. Experience in work with mouse genetic models is desirable but not necessary.

Payscale Salary Range:
UNIV-Band 0: Commensurate with experience.

Job Duties:

  • 30% - Collaborates with the PI and other lab members involved to design and execute experiments using state-of-the-art mouse genetic models, and cells prepared form these models, to study the role of the p53 variants in cancer risk, with a focus on colorectal and liver cancer. These duties include genotyping of genetically-engineered mice and animal husbandry, in vivo experiments, including treatment studies, monitoring for development of disease, necropsies of experimental mice and in vitro studies, including preparing cells from the models, cell culture, molecular and functional genomic evaluation of gene expression and transcription factor binding to target genes, including, RNA-Seq, ChIP-Seq, and proteomics. - (Essential)
  • 30% - Collaborates in collecting and analyzing data generated from the experiments. Duties include keeping accurate records on a daily basis, using appropriate software for analysis of data, and collaborating with Biostatistics and Bioinformatics Research Shared Resources to ensure quality of the results, interpreting results, and planning new experiments. - (Essential)
  • 30% - Collaborates in preparing manuscripts and grants based on the experimental data generated. Duties include keeping current with the literature, preparing figures based on data collected, writing manuscripts and sections of grants with the PI and senior team members, presenting current work in research in progress seminars, attending departmental seminars and participating in journal clubs. - (Essential)
  • 10% - Helps with laboratory maintenance and regulatory compliance, i.e., ordering, cleanup of lab areas, maintenance of equipment, helping to prepare IACUC protocols and amendments when appropriate. - (Essential)

Minimum Experience and Training Requirements:
Ph.D., M.D. or equivalent.

Physical Requirements:
Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32? F to 100? F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/20 vision, corrected. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous)

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

Opening date: 19 Aug 2021 Eastern Daylight Time

Applications close:

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